کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319561 | 1290820 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of the lateral hypothalamus in modulating responses of parabrachial gustatory neurons in the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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![عکس صفحه اول مقاله: Role of the lateral hypothalamus in modulating responses of parabrachial gustatory neurons in the rat Role of the lateral hypothalamus in modulating responses of parabrachial gustatory neurons in the rat](/preview/png/4319561.png)
چکیده انگلیسی
The lateral hypothalamus (LH) receives projections from the parabrachial nucleus (PBN) gustatory neurons and sends efferent projections to the PBN. To examine if the LH is involved in modulating activity of gustatory neurons in the PBN, we examined the effects of electrical stimulation and electrolytic lesions of the LH on the response of PBN gustatory neurons, using extracellular recording techniques. Among 45 PBN taste neurons recorded, 60% were affected by LH stimulation and 73% were affected by LH lesions. During LH stimulation, the responses of most affected PBN neurons were inhibited with the magnitude significantly lower than that obtained before stimulation (PÂ <Â 0.05). In contrast, LH lesions facilitated the response. Based on the best-stimulus category, the responses of the NaCl-best neurons to NaCl and HCl and the QHCl-best neurons to HCl and QHCl were significantly suppressed during LH stimulation (PÂ <Â 0.05). After lesions of the LH, however, the response to HCl in NaCl-best PBN neurons was significantly increased (PÂ <Â 0.05). Analysis of across-unit patterns indicated that LH stimulation decreased the correlations between NaCl and other stimuli, and increased those between QHCl and other stimuli. After LH lesions, the correlations between NaCl and other tastants were higher than those before lesions. These findings suggest that the LH mediates feeding and taste via modulating the activity and chemical selectivity of PBN gustatory neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 77, Issue 4, 22 October 2008, Pages 165-171
Journal: Brain Research Bulletin - Volume 77, Issue 4, 22 October 2008, Pages 165-171
نویسندگان
Qi Lei, Jianqun Yan, Tao Huang, Jinghong Shi, Xuejuan Yang, Bo Lv, Qiang Li,