Genetic, temporal and diurnal influences on L-dopa-induced dyskinesia in the 6-OHDA model

We report that none of the parameters studied - genetic variation within and between strains, delay of treatment onset after lesion, or time of day of the drug treatment - were found to influence directly the formation of dyskinesias after L-dopa treatment. We conclude that a complex combination of individual factors are likely to interact to regulate the onset and development of abnormal movements in some animals but not others.