کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4320316 | 1290859 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidences for calcium-dependent inactivation of calcium current at the frog motor nerve terminal
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evidences for calcium-dependent inactivation of calcium current at the frog motor nerve terminal Evidences for calcium-dependent inactivation of calcium current at the frog motor nerve terminal](/preview/png/4320316.png)
چکیده انگلیسی
Assessment of calcium-dependent inactivation of calcium current in nerve terminals is not feasible due to technical reasons. Perineural measurement of calcium-flow, however, might be utilized as indirect means to evaluate synaptic currents. Using perineural recording from frog neuromuscular junction, supra-threshold stimuli applied to motor nerve in paired-pulse manner with varying inter-pulse intervals (5-50Â ms) are demonstrated in this study to cause paired-pulse depression (PPD) of Ca2+-current. PPD of Ca2+-flow was reduced at lower extracellular Ca2+ concentrations, in BAPTA-AM and EGTA-AM treated preparations and after replacing extracellular Ca2+ with Sr2+. Using perineural measurement of calcium current as an indirect model to investigate synaptic ionic activity, our findings demonstrate that PPD may be attributed to calcium-dependent inactivation of Ca2+-current, which may serve as negative feedback in response to massive Ca2+ entry to motor nerve terminals. A putative sensor of Ca2+-current is also proposed in this study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 69, Issue 6, 31 May 2006, Pages 652-655
Journal: Brain Research Bulletin - Volume 69, Issue 6, 31 May 2006, Pages 652-655
نویسندگان
Marat A. Mukhamedyarov, Sergey N. Grishin, Andrey L. Zefirov, András Palotás,