کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4320618 1291516 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution
چکیده انگلیسی


• Functional network synchronizability predicts spread of seizures before they begin
• Virtual cortical resection reveals network regions that control synchronization
• Control regions strongly synchronize or desynchronize network dynamics
• Weakened push-pull antagonism between control regions explains why seizures spread

SummaryIn ∼20 million people with drug-resistant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and spread to surrounding tissue, disrupting function in otherwise normal brain regions. To identify network control mechanisms that regulate seizure spread, we developed a novel tool for pinpointing brain regions that facilitate synchronization in the epileptic network. Our method measures the impact of virtually resecting putative control regions on synchronization in a validated model of the human epileptic network. By applying our technique to time-varying functional networks, we identified brain regions whose topological role is to synchronize or desynchronize the epileptic network. Our results suggest that greater antagonistic push-pull interaction between synchronizing and desynchronizing brain regions better constrains seizure spread. These methods, while applied here to epilepsy, are generalizable to other brain networks and have wide applicability in isolating and mapping functional drivers of brain dynamics in health and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 91, Issue 5, 7 September 2016, Pages 1170–1182
نویسندگان
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