کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4320729 | 1291528 | 2016 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice](/preview/png/4320729.png)
• Cortical and thalamic inputs to striatal MSN subtypes biased to direct pathway
• Relative strength of thalamic, not cortical, inputs reversed in PD mice
• Asymmetric thalamostriatal drive of MSN subtypes mediated by loss of input to dMSNs
• Chemogenetic or optogenetic inhibition of thalamostriatal synapses rescues PD deficits
SummaryMovement suppression in Parkinson’s disease (PD) is thought to arise from increased efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However, the underlying pathophysiological mechanisms remain elusive. To examine whether changes in the strength of synaptic inputs to these circuits contribute to this imbalance, we obtained paired whole-cell recordings from striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated inputs from sensorimotor cortex or intralaminar thalamus in brain slices from control and dopamine-depleted mice. We found that dopamine depletion selectively decreased synaptic strength at thalamic inputs to dMSNs, suggesting that thalamus drives asymmetric activation of basal ganglia circuitry underlying parkinsonian motor impairments. Consistent with this hypothesis, in vivo chemogenetic and optogenetic inhibition of thalamostriatal terminals reversed motor deficits in dopamine-depleted mice. These results implicate thalamostriatal projections in the pathophysiology of PD and support interventions targeting thalamus as a potential therapeutic strategy.
Journal: - Volume 89, Issue 4, 17 February 2016, Pages 734–740