کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4320818 | 1291539 | 2015 | 18 صفحه PDF | دانلود رایگان |
• Cis-regulatory elements of a pan-neuronal gene battery are functionally defined
• Pan-neuronal genes share a common cis-regulatory architecture
• This architecture is defined by redundant, parallel-acting cis-regulatory modules
• Neuron-type-specific genes are controlled in a distinct manner
SummaryWhile neuronal cell types display an astounding degree of phenotypic diversity, most if not all neuron types share a core panel of terminal features. However, little is known about how pan-neuronal expression patterns are genetically programmed. Through an extensive analysis of the cis-regulatory control regions of a battery of pan-neuronal C. elegans genes, including genes involved in synaptic vesicle biology and neuropeptide signaling, we define a common organizational principle in the regulation of pan-neuronal genes in the form of a surprisingly complex array of seemingly redundant, parallel-acting cis-regulatory modules that direct expression to broad, overlapping domains throughout the nervous system. These parallel-acting cis-regulatory modules are responsive to a multitude of distinct trans-acting factors. Neuronal gene expression programs therefore fall into two fundamentally distinct classes. Neuron-type-specific genes are generally controlled by discrete and non-redundantly acting regulatory inputs, while pan-neuronal gene expression is controlled by diverse, coincident and seemingly redundant regulatory inputs.
Journal: - Volume 87, Issue 4, 19 August 2015, Pages 733–750