کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4321062 1291566 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic Encoding of Perception, Memory, and Movement in a C. elegans Chemotaxis Circuit
ترجمه فارسی عنوان
رمزگذاری دینامیکی ادراک، حافظه و جنبش در یک سیگنال سیاتالگنز شیمیایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Compact encoding of perception, memory, and movement for chemotaxis
• Temporal activity patterns of a sensory neuron encodes perception and memory
• Flexible relays of interneuronal network
• Rapid synaptic transformation of sensory representation to motor representation

SummaryBrain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negative chemotaxis by regulating the frequency and direction of reorientation movements in response to salt gradients. Both salt gradients and set point memory are encoded in ASER temporal activity patterns. Distinct temporal activity patterns in interneurons immediately downstream of ASER encode chemotactic movement decisions. Different interneuron combinations regulate positive versus negative chemotaxis. We conclude that sensorimotor pathways are segregated immediately after the primary sensory neuron in the chemotaxis circuit, and sensory representation is rapidly transformed to motor representation at the first interneuron layer. Our study reveals compact encoding of perception, memory, and locomotion in an experience-dependent navigational behavior in C. elegans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 82, Issue 5, 4 June 2014, Pages 1115–1128
نویسندگان
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