کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4321064 1291566 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurons in the Ventral Striatum Exhibit Cell-Type-Specific Representations of Outcome during Learning
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Neurons in the Ventral Striatum Exhibit Cell-Type-Specific Representations of Outcome during Learning
چکیده انگلیسی


• Plasticity in ventromedial striatum during reward learning is cell-type specific
• Cholinergic interneurons signal outcome and track reinforcement contingencies
• Spiny projection neurons (SPNs) lose outcome responses during learning
• SPNs maintain responses at trial initiation and goal approach during learning

SummaryThe ventromedial striatum (VMS) is a node in circuits underpinning both affect and reinforcement learning. The cellular bases of these functions and especially their potential linkages have been unclear. VMS cholinergic interneurons, however, have been singled out as being related both to affect and to reinforcement-based conditioning, raising the possibility that unique aspects of their signaling could account for these functions. Here we show that VMS tonically active neurons (TANs), including putative cholinergic interneurons, generate unique bidirectional outcome responses during reward-based learning, reporting both positive (reward) and negative (reward omission) outcomes when behavioral change is prompted by switches in reinforcement contingencies. VMS output neurons (SPNs), by contrast, are nearly insensitive to switches in reinforcement contingencies, gradually losing outcome signaling while maintaining responses at trial initiation and goal approach. Thus, TANs and SPNs in the VMS provide distinct signals optimized for different aspects of the learning process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 82, Issue 5, 4 June 2014, Pages 1145–1156
نویسندگان
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