Dystroglycan Adds More Sugars to the Midline Cocktail

In this issue of Neuron, Wright et al. (2012) identify two novel mediators of α-dystroglycan glycosylation in mouse and unravel a novel function of glycosylated dystroglycan in axon guidance by providing evidence for direct binding of α-DG to the midline chemorepellent Slit2.