کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4321651 | 1291641 | 2010 | 8 صفحه PDF | دانلود رایگان |
SummaryPathological behaviors such as problem gambling or shopping are characterized by compulsive choice despite alternative options and negative costs. Reinforcement learning algorithms allow a computation of prediction error, a comparison of actual and expected outcomes, which updates our predictions and influences our subsequent choices. Using a reinforcement learning model, we show data consistent with the idea that dopamine agonists in susceptible individuals with Parkinson's disease increase the rate of learning from gain outcomes. Dopamine agonists also increase striatal prediction error activity, thus signifying a “better than expected” outcome. Thus, our findings are consistent with a model whereby a distorted estimation of the gain cue underpins a choice bias toward gains.
► Dopamine agonists (DA) hasten reward learning in susceptible individuals
► DA increase striatal gain prediction error in susceptible individuals
► “Better than expected” outcomes may drive compulsive behavior in Parkinson's disease
Journal: - Volume 65, Issue 1, 14 January 2010, Pages 135–142