کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4321805 | 1291652 | 2012 | 15 صفحه PDF | دانلود رایگان |
SummaryAt the optic chiasm, retinal ganglion cells (RGCs) project ipsi- or contralaterally to establish the circuitry for binocular vision. Ipsilateral guidance programs have been characterized, but contralateral guidance programs are not well understood. Here, we identify a tripartite molecular system for contralateral RGC projections: Semaphorin6D (Sema6D) and Nr-CAM are expressed on midline radial glia and Plexin-A1 on chiasm neurons, and Plexin-A1 and Nr-CAM are also expressed on contralateral RGCs. Sema6D is repulsive to contralateral RGCs, but Sema6D in combination with Nr-CAM and Plexin-A1 converts repulsion to growth promotion. Nr-CAM functions as a receptor for Sema6D. Sema6D, Plexin-A1, and Nr-CAM are all required for efficient RGC decussation at the optic chiasm. These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on RGCs to implement the contralateral RGC projection.
► Plexin-A1 and Nr-CAM are expressed in contralateral RGCs and the optic chiasm midline
► Nr-CAM and Plexin-A1 modulate inhibition by midline Sema6D
► Nr-CAM is a receptor for Sema6D and binds to Plexin-A1
► Proper RGC axon fasciculation and decussation are dependent on all three factors
Journal: - Volume 74, Issue 4, 24 May 2012, Pages 676–690