کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4321858 1291658 2010 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins
چکیده انگلیسی

SummaryTransmembrane AMPA receptor regulatory proteins (TARPs) and cornichon proteins (CNIH-2/3) independently modulate AMPA receptor trafficking and gating. However, the potential for interactions of these subunits within an AMPA receptor complex is unknown. Here, we find that TARPs γ-4, γ-7, and γ-8, but not γ-2, γ-3, or γ-5, cause AMPA receptors to “resensitize” upon continued glutamate application. With γ-8, resensitization occurs with all GluA subunit combinations; however, γ-8-containing hippocampal neurons do not display resensitization. In recombinant systems, CNIH-2 abrogates γ-8-mediated resensitization and modifies AMPA receptor pharmacology and gating to match that of hippocampal neurons. In hippocampus, γ-8 and CNIH-2 associate in postsynaptic densities and CNIH-2 protein levels are markedly diminished in γ-8 knockout mice. Manipulating neuronal CNIH-2 levels modulates the electrophysiological properties of extrasynaptic and synaptic γ-8-containing AMPA receptors. Thus, γ-8 and CNIH-2 functionally interact with common hippocampal AMPA receptor complexes to modulate synergistically kinetics and pharmacology.


► TARP and cornichon subunits synergistically modulate hippocampal AMPA receptors
► AMPA receptor resensitization induced by TARP subunits

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 68, Issue 6, 22 December 2010, Pages 1082–1096
نویسندگان
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