کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4321862 1291658 2010 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis
چکیده انگلیسی

SummaryHomeostatic synaptic plasticity is important for maintaining stability of neuronal function, but heterogeneous expression mechanisms suggest that distinct facets of neuronal activity may shape the manner in which compensatory synaptic changes are implemented. Here, we demonstrate that local presynaptic activity gates a retrograde form of homeostatic plasticity induced by blockade of AMPA receptors (AMPARs) in cultured hippocampal neurons. We show that AMPAR blockade produces rapid (<3 hr) protein synthesis-dependent increases in both presynaptic and postsynaptic function and that the induction of presynaptic, but not postsynaptic, changes requires coincident local activity in presynaptic terminals. This “state-dependent” modulation of presynaptic function requires postsynaptic release of brain-derived neurotrophic factor (BDNF) as a retrograde messenger, which is locally synthesized in dendrites in response to AMPAR blockade. Taken together, our results reveal a local crosstalk between active presynaptic terminals and postsynaptic signaling that dictates the manner by which homeostatic plasticity is implemented at synapses.


► AMPAR blockade drives homeostatic retrograde enhancement of presynaptic function
► Local presynaptic activity gates compensatory increase in release probability
► Postsynaptic BDNF synthesis and release mediates retrograde signaling
► BDNF is locally synthesized in dendrites in response to AMPAR blockade

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 68, Issue 6, 22 December 2010, Pages 1143–1158
نویسندگان
, , , , , , , ,