کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4321894 1291660 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Obesity-Blocking Neurons in Drosophila
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Obesity-Blocking Neurons in Drosophila
چکیده انگلیسی

SummaryIn mammals, fat store levels are communicated by leptin and insulin signaling to brain centers that regulate food intake and metabolism. By using transgenic manipulation of neural activity, we report the isolation of two distinct neuronal populations in flies that perform a similar function, the c673a-Gal4 and fruitless-Gal4 neurons. When either of these neuronal groups is silenced, fat store levels increase. This change is mediated through an increase in food intake and altered metabolism in c673a-Gal4-silenced flies, while silencing fruitless-Gal4 neurons alters only metabolism. Hyperactivation of either neuronal group causes depletion of fat stores by increasing metabolic rate and decreasing fatty acid synthesis. Altering the activities of these neurons causes changes in expression of genes known to regulate fat utilization. Our results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 63, Issue 3, 13 August 2009, Pages 329–341
نویسندگان
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