کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4321895 1291660 2009 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation
چکیده انگلیسی

SummaryNR3A is the only NMDA receptor (NMDAR) subunit that downregulates sharply prior to the onset of sensitive periods for plasticity, yet the functional importance of this transient expression remains unknown. To investigate whether removal/replacement of juvenile NR3A-containing NMDARs is involved in experience-driven synapse maturation, we used a reversible transgenic system that prolonged NR3A expression in the forebrain. We found that removal of NR3A is required to develop strong NMDAR currents, full expression of long-term synaptic plasticity, a mature synaptic organization characterized by more synapses and larger postsynaptic densities, and the ability to form long-term memories. Deficits associated with prolonged NR3A were reversible, as late-onset suppression of transgene expression rescued both synaptic and memory impairments. Our results suggest that NR3A behaves as a molecular brake to prevent the premature strengthening and stabilization of excitatory synapses and that NR3A removal might thereby initiate critical stages of synapse maturation during early postnatal neural development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 63, Issue 3, 13 August 2009, Pages 342–356
نویسندگان
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