Odor Representations in Olfactory Cortex: “Sparse” Coding, Global Inhibition, and Oscillations

SummaryThe properties of cortical circuits underlying central representations of sensory stimuli are poorly understood. Here we use in vivo cell-attached and whole-cell voltage-clamp recordings to reveal how excitatory and inhibitory synaptic input govern odor representations in rat primary olfactory (piriform) cortex. We show that odors evoke spiking activity that is sparse across the cortical population. We find that unbalanced synaptic excitation and inhibition underlie sparse activity: inhibition is widespread and broadly tuned, while excitation is less common and odor-specific. “Global” inhibition can be explained by local interneurons that receive ubiquitous and nonselective odor-evoked excitation. In the temporal domain, while respiration imposes a slow rhythm to olfactory cortical responses, odors evoke fast (15-30 Hz) oscillations in synaptic activity. Oscillatory excitation precedes inhibition, generating brief time windows for precise and temporally sparse spike output. Together, our results reveal that global inhibition and oscillations are major synaptic mechanisms shaping odor representations in olfactory cortex.