کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322051 1291678 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat
چکیده انگلیسی

SummaryTransient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca2+-permeable nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 by the neuroactive steroid pregnenolone sulfate (PS), but its in vivo gating mechanisms and functions remained poorly understood. Here, we provide evidence that TRPM3 functions as a chemo- and thermosensor in the somatosensory system. TRPM3 is molecularly and functionally expressed in a large subset of small-diameter sensory neurons from dorsal root and trigeminal ganglia, and mediates the aversive and nocifensive behavioral responses to PS. Moreover, we demonstrate that TRPM3 is steeply activated by heating and underlies heat sensitivity in a subset of sensory neurons. TRPM3-deficient mice exhibited clear deficits in their avoidance responses to noxious heat and in the development of inflammatory heat hyperalgesia. These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat.


► TRPM3 is functionally expressed in a large subpopulation of sensory neurons
► The TRPM3 agonist evokes pain and aversion in WT, but not in TRPM3-deficient mice
► TRPM3 is steeply activated by heat
► TRPM3−/− mice exhibit specific deficiencies in their response to noxious heat stimuli

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 70, Issue 3, 12 May 2011, Pages 482–494
نویسندگان
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