کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322063 1291679 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity
چکیده انگلیسی

SummaryMajor histocompatibility complex class I (MHCI) genes were discovered unexpectedly in healthy CNS neurons in a screen for genes regulated by neural activity. In mice lacking just 2 of the 50+ MHCI genes H2-Kb and H2-Db, ocular dominance (OD) plasticity is enhanced. Mice lacking PirB, an MHCI receptor, have a similar phenotype. H2-Kb and H2-Db are expressed not only in visual cortex, but also in lateral geniculate nucleus (LGN), where protein localization correlates strongly with synaptic markers and complement protein C1q. In KbDb−/− mice, developmental refinement of retinogeniculate projections is impaired, similar to C1q−/− mice. These phenotypes in KbDb−/− mice are strikingly similar to those in β2 m−/−TAP1−/− mice, which lack cell surface expression of all MHCIs, implying that H2-Kb and H2-Db can account for observed changes in synapse plasticity. H2-Kb and H2-Db ligands, signaling via neuronal MHCI receptors, may enable activity-dependent remodeling of brain circuits during developmental critical periods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 64, Issue 4, 25 November 2009, Pages 463–470
نویسندگان
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