کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322108 1291681 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metaplasticity Governs Natural Experience-Driven Plasticity of Nascent Embryonic Brain Circuits
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Metaplasticity Governs Natural Experience-Driven Plasticity of Nascent Embryonic Brain Circuits
چکیده انگلیسی

SummaryDuring embryogenesis, brain neurons receiving the same sensory input may undergo potentiation or depression. While the origin of variable plasticity in vivo is unknown, it plays a key role in shaping dynamic neural circuit refinement. Here, we investigate effects of natural visual stimuli on neuronal firing within the intact, awake, developing brain using calcium imaging of 100 s of central neurons in the Xenopus retinotectal system. We find that specific patterns of visual stimuli shift population responses toward either potentiation or depression in an N-methyl-D-aspartate receptor (NMDA-R)-dependent manner. In agreement with Bienenstock-Cooper-Munro metaplasticity, our results show that functional potentiation or depression can be predicted by individual neurons' specific receptive field properties and historic firing rates. Interestingly, this activity-dependent metaplasticity is itself NMDA-R dependent. Furthermore, network analysis reveals increased correlated firing of neurons that undergo potentiation. These findings implicate metaplasticity as a natural property regulating experience-dependent refinement of nascent embryonic brain circuits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 64, Issue 2, 29 October 2009, Pages 240–250
نویسندگان
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