کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322148 1291683 2009 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse
چکیده انگلیسی

SummaryThe repertoire of ∼1200 odorant receptors (ORs) is mapped onto the array of ∼1800 glomeruli in the mouse olfactory bulb (OB). The spatial organization of this array is influenced by the ORs. Here we show that glomerular mapping to broad domains in the dorsal OB is determined by two types of olfactory sensory neurons (OSNs), which reside in the dorsal olfactory epithelium. The OSN types express either class I or class II OR genes. Axons from the two OSN types segregate already within the olfactory nerve and form distinct domains of glomeruli in the OB. These class-specific anatomical domains correlate with known functional odorant response domains. However, axonal segregation and domain formation are not determined by the class of the expressed OR protein. Thus, the two OSN types are determinants of axonal wiring, operate at a higher level than ORs, and contribute to the functional organization of the glomerular array.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 61, Issue 2, 29 January 2009, Pages 220–233
نویسندگان
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