کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4322188 | 1291689 | 2009 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons](/preview/png/4322188.png)
SummaryAn activity-dependent form of intermediate memory (AD-ITM) for sensitization is induced in Aplysia by a single tail shock that gives rise to plastic changes (AD-ITF) in tail sensory neurons (SNs) via the interaction of action potential firing in the SN coupled with the release of serotonin in the CNS. Activity-dependent long-term facilitation (AD-LTF, lasting >24hr) requires protein synthesis dependent persistent mitogen-activated protein kinase (MAPK) activation and translocation to the SN nucleus. We now show that the induction of the earlier temporal phase (AD-ITM and AD-ITF), which is translation and transcription independent, requires the activation of a compartmentally distinct novel signaling cascade that links second messengers, MAPK and PKC into a unified pathway within tail SNs. Since both AD-ITM and AD-LTM require MAPK activity, these collective findings suggest that presynaptic SNs route the flow of molecular information to distinct subcellular compartments during the induction of activity-dependent long-lasting memories.
Journal: - Volume 61, Issue 1, 15 January 2009, Pages 113–125