کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4322367 | 1291701 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direction Selectivity in the Retina Is Established Independent of Visual Experience and Cholinergic Retinal Waves
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
SummaryDirection selectivity in the retina requires the asymmetric wiring of inhibitory inputs onto four subtypes of On-Off direction-selective ganglion cells (DSGCs), each preferring motion in one of four cardinal directions. The primary model for the development of direction selectivity is that patterned activity plays an instructive role. Here, we use a unique, large-scale multielectrode array to demonstrate that DSGCs are present at eye opening, in mice that have been reared in darkness and in mice that lack cholinergic retinal waves. These data suggest that direction selectivity in the retina is established largely independent of patterned activity and is therefore likely to emerge as a result of complex molecular interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 58, Issue 4, 22 May 2008, Pages 499–506
Journal: - Volume 58, Issue 4, 22 May 2008, Pages 499–506
نویسندگان
Justin Elstrott, Anastasia Anishchenko, Martin Greschner, Alexander Sher, Alan M. Litke, E.J. Chichilnisky, Marla B. Feller,