کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322483 1291711 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE
چکیده انگلیسی

SummaryMatrix metalloproteases (MMPs) play a role in remodeling the extracellular matrix during brain development and have been implicated in synaptic plasticity. Here, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage by the MMP tumor necrosis factor-α converting enzyme (TACE). NPR is enriched at excitatory synapses where it associates with AMPA-type glutamate receptors (AMPAR) and enhances synaptogenesis. However, in response to activation of group 1 mGluRs (mGluR1/5), TACE cleaves NPR and releases the pentraxin domain from its N-terminal transmembrane domain. Cleaved NPR rapidly accumulates in endosomes where it colocalizes with AMPAR. This process is necessary for mGluR1/5-dependent LTD in hippocampal and cerebellar synapses. These observations suggest that cleaved NPR functions to “capture” AMPAR for endocytosis and reveal a bifunctional role of NPs in both synapse strengthening and weakening.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 57, Issue 6, 27 March 2008, Pages 858–871
نویسندگان
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