کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322574 1291718 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Zfp423/OAZ Participates in a Developmental Switch during Olfactory Neurogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Zfp423/OAZ Participates in a Developmental Switch during Olfactory Neurogenesis
چکیده انگلیسی

SummaryThe coordination of gene expression is critical for cell differentiation and the subsequent establishment of tissue function. We show here that a multiple zinc finger transcription factor, Zfp423/OAZ, is transiently expressed in newly differentiating olfactory-receptor neurons (ORNs) and has a key role in coordinating the expression of immature and mature stage-specific genes. OAZ deletion in mice impairs aspects of ORN differentiation, particularly the patterns of axonal projection to the olfactory bulb. OAZ gain-of-function experiments show that sustained OAZ expression throughout ORN maturation arrests ORN development at an immature stage and alters OR gene expression. Importantly, reintroducing OAZ expression in mature ORNs suppresses mature marker expression and reactivates immature-specific markers. Together, these experiments suggest that OAZ participates in a developmental switch regulating the transition from differentiation to maturation in ORNs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 54, Issue 4, 24 May 2007, Pages 547–557
نویسندگان
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