کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322575 1291718 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
چکیده انگلیسی

SummaryActive adult neurogenesis occurs in discrete brain regions of all mammals and is widely regarded as a neuronal replacement mechanism. Whether adult-born neurons make unique contributions to brain functions is largely unknown. Here we systematically characterized synaptic plasticity of retrovirally labeled adult-born dentate granule cells at different stages during their neuronal maturation. We identified a critical period between 1 and 1.5 months of the cell age when adult-born neurons exhibit enhanced long-term potentiation with increased potentiation amplitude and decreased induction threshold. Furthermore, such enhanced plasticity in adult-born neurons depends on developmentally regulated synaptic expression of NR2B-containing NMDA receptors. Our study demonstrates that adult-born neurons exhibit the same classic critical period plasticity as neurons in the developing nervous system. The transient nature of such enhanced plasticity may provide a fundamental mechanism allowing adult-born neurons within the critical period to serve as major mediators of experience-induced plasticity while maintaining stability of the mature circuitry.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 54, Issue 4, 24 May 2007, Pages 559–566
نویسندگان
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