کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322706 1291725 2007 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors
چکیده انگلیسی

SummaryDuring development, neural precursors migrate in response to positional cues such as growth factor gradients. However, the mechanisms that enable precursors to sense and respond to such gradients are poorly understood. Here we show that cerebellar granule cell precursors (GCPs) migrate along a gradient of brain-derived neurotrophic factor (BDNF), and we demonstrate that vesicle trafficking is critical for this chemotactic process. Activation of TrkB, the BDNF receptor, stimulates GCPs to secrete BDNF, thereby amplifying the ambient gradient. The BDNF gradient stimulates endocytosis of TrkB and associated signaling molecules, causing asymmetric accumulation of signaling endosomes at the subcellular location where BDNF concentration is maximal. Thus, regulated BDNF exocytosis and TrkB endocytosis enable precursors to polarize and migrate in a directed fashion along a shallow BDNF gradient.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 55, Issue 1, 5 July 2007, Pages 53–68
نویسندگان
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