کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4322773 | 1291730 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-Recognition at the Atomic Level: Understanding the Astonishing Molecular Diversity of Homophilic Dscams
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Self-Recognition at the Atomic Level: Understanding the Astonishing Molecular Diversity of Homophilic Dscams Self-Recognition at the Atomic Level: Understanding the Astonishing Molecular Diversity of Homophilic Dscams](/preview/png/4322773.png)
چکیده انگلیسی
The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key role in self-avoidance between sister branches from neurons, which depends on homophilic self-recognition by Dscams. Two recent papers shed new light on Dscam recognition: first by showing that the vast majority of Dscam isoforms mediate specific homophilic binding and second by revealing the essence of the molecular basis of homophilic recognition by Dscams through high-resolution structural studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 56, Issue 1, 4 October 2007, Pages 10–13
Journal: - Volume 56, Issue 1, 4 October 2007, Pages 10–13
نویسندگان
Lawrence Shapiro,