کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4322813 | 1291733 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
SummaryArc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 52, Issue 3, 9 November 2006, Pages 437–444
Journal: - Volume 52, Issue 3, 9 November 2006, Pages 437–444
نویسندگان
Niels Plath, Ora Ohana, Björn Dammermann, Mick L. Errington, Dietmar Schmitz, Christina Gross, Xiaosong Mao, Arne Engelsberg, Claudia Mahlke, Hans Welzl, Ursula Kobalz, Anastasia Stawrakakis, Esperanza Fernandez, Robert Waltereit, Anika Bick-Sander,