کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322848 1291735 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Notch and MAML Signaling Drives Scl-Dependent Interneuron Diversity in the Spinal Cord
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Notch and MAML Signaling Drives Scl-Dependent Interneuron Diversity in the Spinal Cord
چکیده انگلیسی

SummaryThe ventral spinal cord generates multiple inhibitory and excitatory interneuron subtypes from four cardinal progenitor domains (p0, p1, p2, p3). Here we show that cell-cell interactions mediated by the Notch receptor play a critical evolutionarily conserved role in the generation of excitatory v2aIN and inhibitory v2bIN interneurons. Lineage-tracing experiments show that the v2aIN and v2bIN develop from genetically identical p2 progenitors. The p2 daughter cell fate is controlled by Delta4 activation of Notch receptors together with MAML factors. Cells receiving Notch signals activate a transcription factor code that specifies the v2bIN fate, whereas cells deprived of Notch signaling express another code for v2aIN formation. Thus, our study provides insight into the cell-extrinsic signaling that controls combinatorial transcription factor profiles involved in regulating the process of interneuron subtype diversification.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 53, Issue 6, 15 March 2007, Pages 813–827
نویسندگان
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