کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4322902 | 1291741 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drosophila Neuroblast Asymmetric Cell Division: Recent Advances and Implications for Stem Cell Biology
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Asymmetric cell division is an evolutionarily conserved mechanism widely used to generate cellular diversity during development. Drosophila neuroblasts have been a useful model system for studying the molecular mechanisms of asymmetric cell division. In this minireview, we focus on recent progress in understanding the role of heterotrimeric G proteins and their regulators in asymmetric spindle geometry, as well as the role of an Inscuteable-independent microtubule pathway in asymmetric localization of proteins in neuroblasts. We also discuss issues of progenitor proliferation and differentiation associated with asymmetric cell division and their broader implications for stem cell biology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 51, Issue 1, 6 July 2006, Pages 13–20
Journal: - Volume 51, Issue 1, 6 July 2006, Pages 13–20
نویسندگان
Fengwei Yu, Chay T. Kuo, Yuh Nung Jan,