کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4322983 1613435 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
FGF as a Target-Derived Chemoattractant for Developing Motor Axons Genetically Programmed by the LIM Code
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
FGF as a Target-Derived Chemoattractant for Developing Motor Axons Genetically Programmed by the LIM Code
چکیده انگلیسی

SummaryLIM transcription factors confer developing axons with specific navigational properties, but the downstream guidance receptors and ligands are not well defined. The dermomyotome, a transient structure from which axial muscles arise, is the source of a secreted long-range chemoattractant specific for medial-class spinal motor neuron axons (MMCm axons). We show that fibroblast growth factors (FGFs) produced by the dermomyotome selectively attract MMCm axons in vitro. FGF receptor 1 (FGFR1) expression is restricted to MMCm neurons, and conditional deletion of FGFR1 causes motor axon guidance defects. Furthermore, reprogramming the identity of limb-innervating motor neurons to that of dermomyotome-innervating MMCm cells using the LIM factor Lhx3 induces FGFR1 expression and shifts an increased number of motor axons to an FGF-responsive state. These results point to a role for FGF signaling in axon guidance and further unravel how downstream effectors of LIM codes direct wiring of the developing nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 50, Issue 6, 15 June 2006, Pages 841–853
نویسندگان
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