کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323004 1291747 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
چکیده انگلیسی

SummaryDuring development, the healthy human brain constructs a host of large-scale, distributed, function-critical neural networks. Neurodegenerative diseases have been thought to target these systems, but this hypothesis has not been systematically tested in living humans. We used network-sensitive neuroimaging methods to show that five different neurodegenerative syndromes cause circumscribed atrophy within five distinct, healthy, human intrinsic functional connectivity networks. We further discovered a direct link between intrinsic connectivity and gray matter structure. Across healthy individuals, nodes within each functional network exhibited tightly correlated gray matter volumes. The findings suggest that human neural networks can be defined by synchronous baseline activity, a unified corticotrophic fate, and selective vulnerability to neurodegenerative illness. Future studies may clarify how these complex systems are assembled during development and undermined by disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 62, Issue 1, 16 April 2009, Pages 42–52
نویسندگان
, , , , ,