کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323114 1291752 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuroligins Determine Synapse Maturation and Function
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Neuroligins Determine Synapse Maturation and Function
چکیده انگلیسی

SummarySynaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic α- and β-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 51, Issue 6, 21 September 2006, Pages 741–754
نویسندگان
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