کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4323193 | 1291756 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
SummaryThe neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we demonstrate that KCC2, independently of its Cl− transport function, is a key factor in the maturation of dendritic spines. This morphogenic role of KCC2 in the development of excitatory synapses is mediated by structural interactions between KCC2 and the spine cytoskeleton. Here, the binding of KCC2 C-terminal domain to the cytoskeleton-associated protein 4.1N may play an important role. A more general conclusion based on our data is that KCC2 acts as a synchronizing factor in the functional development of glutamatergic and GABAergic synapses in cortical neurons and networks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 56, Issue 6, 20 December 2007, Pages 1019–1033
Journal: - Volume 56, Issue 6, 20 December 2007, Pages 1019–1033
نویسندگان
Hong Li, Stanislav Khirug, Chunlin Cai, Anastasia Ludwig, Peter Blaesse, Julia Kolikova, Ramil Afzalov, Sarah K. Coleman, Sari Lauri, Matti S. Airaksinen, Kari Keinänen, Leonard Khiroug, Mart Saarma, Kai Kaila, Claudio Rivera,