کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323236 1291761 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vesicular Glutamate Transport at a Central Synapse Limits the Acuity of Visual Perception in Zebrafish
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Vesicular Glutamate Transport at a Central Synapse Limits the Acuity of Visual Perception in Zebrafish
چکیده انگلیسی

SummaryThe neural circuitry that constrains visual acuity in the CNS has not been experimentally identified. We show here that zebrafish blumenkohl (blu) mutants are impaired in resolving rapid movements and fine spatial detail. The blu gene encodes a vesicular glutamate transporter expressed by retinal ganglion cells. Mutant retinotectal synapses release less glutamate, per vesicle and per terminal, and fatigue more quickly than wild-type in response to high-frequency stimulation. In addition, mutant axons arborize more extensively, thus increasing the number of synaptic terminals and effectively normalizing the combined input to postsynaptic cells in the tectum. This presumably homeostatic response results in larger receptive fields of tectal cells and a degradation of the retinotopic map. As predicted, mutants have a selective deficit in the capture of small prey objects, a behavior dependent on the tectum. Our studies successfully link the disruption of a synaptic protein to complex changes in neural circuitry and behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 53, Issue 1, 4 January 2007, Pages 65–77
نویسندگان
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