کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4323239 | 1291761 | 2007 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sequential Use of Mushroom Body Neuron Subsets during Drosophila Odor Memory Processing Sequential Use of Mushroom Body Neuron Subsets during Drosophila Odor Memory Processing](/preview/png/4323239.png)
SummaryDrosophila mushroom bodies (MB) are bilaterally symmetric multilobed brain structures required for olfactory memory. Previous studies suggested that neurotransmission from MB neurons is only required for memory retrieval. Our unexpected observation that Dorsal Paired Medial (DPM) neurons, which project only to MB neurons, are required during memory storage but not during acquisition or retrieval, led us to revisit the role of MB neurons in memory processing. We show that neurotransmission from the α′β′ subset of MB neurons is required to acquire and stabilize aversive and appetitive odor memory, but is dispensable during memory retrieval. In contrast, neurotransmission from MB αβ neurons is only required for memory retrieval. These data suggest a dynamic requirement for the different subsets of MB neurons in memory and are consistent with the notion that recurrent activity in an MB α′β′ neuron-DPM neuron loop is required to stabilize memories formed in the MB αβ neurons.
Journal: - Volume 53, Issue 1, 4 January 2007, Pages 103–115