کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323255 1291762 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
چکیده انگلیسی

SummaryBeta amyloid (Aβ), a peptide generated from the amyloid precursor protein (APP) by neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent studies indicate that this peptide can drive loss of surface AMPA and NMDA type glutamate receptors. We now show that Aβ employs signaling pathways of long-term depression (LTD) to drive endocytosis of synaptic AMPA receptors. Synaptic removal of AMPA receptors is necessary and sufficient to produce loss of dendritic spines and synaptic NMDA responses. Our studies indicate the central role played by AMPA receptor trafficking in Aβ-induced modification of synaptic structure and function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 52, Issue 5, 7 December 2006, Pages 831–843
نویسندگان
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