کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4323256 | 1291762 | 2006 | 11 صفحه PDF | دانلود رایگان |
SummaryFunctional optical imaging showed that odor or electric shock stimuli presented to the fly causes transient calcium influx into the two major axon branches of α/β mushroom body (MB) neurons. One pairing of odor and electric shock stimuli or multiple, massed pairings did not alter odor-evoked calcium influx. In contrast, animals that received multiple, spaced pairings exhibited a robust increase in calcium influx into the MB axons when tested at 9 or 24 hr after training, but not at 3 hr. This modification occurred only in the α branch of the neurons and was blocked by mutation of the amnesiac gene, inhibition of protein synthesis, or the expression of a protein blocker of the transcription factor Creb. Thus, behavioral long-term olfactory memory appears to be encoded as a branch-specific modification of calcium influx into the α/β MB neurons that occurs after spaced training in a protein synthesis-, Creb-, and amnesiac-dependent way.
Journal: - Volume 52, Issue 5, 7 December 2006, Pages 845–855