کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323309 1291765 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SALM Synaptic Cell Adhesion-like Molecules Regulate the Differentiation of Excitatory Synapses
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
SALM Synaptic Cell Adhesion-like Molecules Regulate the Differentiation of Excitatory Synapses
چکیده انگلیسی

SummarySynaptic cell adhesion molecules (CAMs) are known to play key roles in various aspects of synaptic structures and functions, including early differentiation, maintenance, and plasticity. We herein report the identification of a family of cell adhesion-like molecules termed SALM that interacts with the abundant postsynaptic density (PSD) protein PSD-95. SALM2, a SALM isoform, distributes to excitatory, but not inhibitory, synaptic sites. Overexpression of SALM2 increases the number of excitatory synapses and dendritic spines. Mislocalized expression of SALM2 disrupts excitatory synapses and dendritic spines. Bead-induced direct aggregation of SALM2 results in coclustering of PSD-95 and other postsynaptic proteins, including GKAP and AMPA receptors. Knockdown of SALM2 by RNA interference reduces the number of excitatory synapses and dendritic spines and the frequency, but not amplitude, of miniature excitatory postsynaptic currents. These results suggest that SALM2 is an important regulator of the differentiation of excitatory synapses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 50, Issue 2, 20 April 2006, Pages 233–245
نویسندگان
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