کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4323313 | 1291765 | 2006 | 17 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons](/preview/png/4323313.png)
SummaryAlthough radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns (∼20 inputs within ∼6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments.
Journal: - Volume 50, Issue 2, 20 April 2006, Pages 291–307