کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323441 1291775 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases
چکیده انگلیسی

Accumulating evidence indicates that cyclin dependent kinase 5 (Cdk5), through phosphorylating a plethora of pre- and postsynaptic proteins, functions as an essential modulator of synaptic transmission. Recent advances in the field of Cdk5 research have not only consolidated the in vivo importance of Cdk5 in neurotransmission but also suggest a pivotal role of Cdk5 in the regulation of higher cognitive functions and neurodegenerative diseases. In this review, we will discuss the recent findings on the emanating role of Cdk5 as a regulator of synaptic functions and plasticity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 50, Issue 1, 6 April 2006, Pages 13–18
نویسندگان
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