کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4323472 | 1291776 | 2006 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Threshold Behavior in the Initiation of Hippocampal Population Bursts Threshold Behavior in the Initiation of Hippocampal Population Bursts](/preview/png/4323472.png)
SummaryHippocampal population discharges such as sharp waves, epileptiform firing, and GDPs recur at long and variable intervals. The mechanisms for their precise timing are not well understood. Here, we show that population bursts in the disinhibited CA3 region are initiated at a threshold level of population firing after recovery from a previous event. Each population discharge follows an active buildup period when synaptic traffic and cell firing increase to threshold levels. Single-cell firing can advance burst onset by increasing population firing to suprathreshold values. Population synchrony is suppressed when threshold frequencies cannot be reached due to reduced cellular excitability or synaptic efficacy. Reducing synaptic strength reveals partially synchronous population bursts that are curtailed by GABAB-mediated conductances. Excitatory glutamatergic transmission and delayed GABAB-mediated signals have opposing feedback effects on CA3 cell firing and so determine threshold behavior for population synchrony.
Journal: - Volume 49, Issue 1, 5 January 2006, Pages 131–142