کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323720 1613807 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delayed localized hypothermia reduces intracranial pressure following collagenase-induced intracerebral hemorrhage in rat
ترجمه فارسی عنوان
هیپوترمی تاخیری موضعی باعث کاهش فشار داخل جمجمه ای به دنبال خونریزی داخل مغزی ناشی از کلاژناز می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Intracranial pressure rises for days after intracerebral hemorrhage in rats.
• Delayed local brain hypothermia persistently reduces intracranial pressure.
• Delayed cooling did not mitigate cerebral edema.
• Rapid re-warming causes re-bound edema after focal brain cooling.

Brain injury, such as from intracerebral hemorrhage (ICH), causes edema and raises intracranial pressure (ICP) – a potentially life-threatening complication. Clinical studies suggest that therapeutic hypothermia (TH) reduces edema and ICP after ICH. Similarly, animal studies show that TH can sometimes reduce edema, but whether ICP would be attenuated is not known. Here we tested whether 24-h delayed TH reduces edema and ICP in rats with severe striatal ICH (collagenase model). First, we showed that ICH increased epidural ICP (mean of 18 vs. 6.5 mm Hg in controls), measured via telemetry. Second, we confirmed that delayed TH did not affect hematoma size at 7 day (~65 vs. ~61 µL in controls). A cranial cooling device lowered striatal temperature to ~33 °C from 24 to 72 h after ICH. Third, we compared normothermic rats to those with TH that were rewarmed immediately or over 6 h. Both TH protocols significantly reduced average and peak ICP by the second treatment day, and benefits persisted after rewarming. However, TH with slow rewarming failed to mitigate edema at 96 h (83.2% vs. 83.6% in controls) whereas rapid rewarming worsened edema (85.7%). Finally, we compared normothermic and TH rats without rewarming and found no impact on edema at 72 h (~81%). In summary, it appears that 24-h delayed local TH lowers ICP by a mechanism other than edema. Rapid rewarming worsens edema after local cooling, but this did not markedly impact ICP. Thus, TH should reduce ICP in patients with severe ICH, but not necessarily through mitigating edema.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1633, 15 February 2016, Pages 27–36
نویسندگان
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