کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4323918 | 1613833 | 2015 | 9 صفحه PDF | دانلود رایگان |
• Traumatic brain injury (TBI) may occur before or after exposure to a fearful event.
• Fear extinction, modeled in rodents, is impaired in humans with anxiety disorders.
• We combine injury by controlled cortical impact (CCI) with fear extinction in mice.
• CCI delivered before or after conditioning did not affect fear extinction memories.
• Fear learning and extinction remain unimpaired within the first 2 weeks after CCI.
Post-traumatic stress disorder (PTSD) is characterized in part by impaired extinction of conditioned fear. Traumatic brain injury (TBI) is thought to be a risk factor for development of PTSD. We tested the hypothesis that controlled cortical impact (CCI) would impair extinction of fear learned by Pavlovian conditioning, in mice. To mimic the scenarios in which TBI occurs prior to or after exposure to an aversive event, severe CCI was delivered to the left parietal cortex at one of two time points: (1) Prior to fear conditioning, or (2) after conditioning. Delay auditory conditioning was achieved by pairing a tone with a foot shock in “context A”. Extinction training involved the presentation of tones in a different context (context B) in the absence of foot shock. Test for extinction memory was achieved by presentation of additional tones alone in context B over the following two days. In pre- or post-injury paradigms, CCI did not influence fear learning and extinction. Furthermore, CCI did not affect locomotor activity or elevated plus maze testing. Our results demonstrate that, within the time frame studied, CCI does not impair the acquisition and expression of conditioned fear or extinction memory.
Journal: Brain Research - Volume 1606, 5 May 2015, Pages 133–141