کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4324399 1613885 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: An electrophysiological study
ترجمه فارسی عنوان
بررسی اثربخشی دگزامتازون بر فعالیت پپتی لیپوپروتئین در موش صحرایی: مطالعه الکتروفیزیولوژیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• In this study the effect of DEX on epileptiform activity was investigated in rats.
• DEX decreased the epileptiform activity.
• DEX has no potential to exacerbate the epileptiform activity.

Corticosteroids are extensively used in treatment of many diseases. In neurosurgery practice, dexamethasone (DEX) is commonly used particularly in cerebral edema secondary to brain tumors, head trauma, and central nervous system infections. There are some uncertainties surrounding the secure use of DEX in patients with epilepsy or seizures induced by diseases of the central nervous system such as head trauma and brain tumors. Despite its extensive use, the effect of DEX on epileptiform activity is unclear. In this study the effect of DEX on epileptiform activity was investigated in rats. The effects of 1, 3, and 10 mg/kg DEX on epileptiform activity was compared with effects of antiepileptic drugs commonly employed in treatment of epilepsy, namely phenytoin (PHT) 50 mg/kg and levetiracetam (LEV) 50 mg/kg that were administered intraperitoneally for 1 week. All groups were administered intracortical penicillin (500 IU) to induce epileptiform activity. DEX at the doses of 3 mg/kg and 10 mg/kg significantly reduced spike frequencies compared to the initial values. In conclusion, we think that DEX can effectively decrease the epileptiform activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1554, 20 March 2014, Pages 67–72
نویسندگان
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