کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4324583 | 1613912 | 2013 | 15 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preparatory attention after lesions to the lateral or orbital prefrontal cortex – An event-related potentials study Preparatory attention after lesions to the lateral or orbital prefrontal cortex – An event-related potentials study](/preview/png/4324583.png)
• We investigate the role of two main prefrontal cortex subregions.
• We examine the effect of lesions on contingent negative variation generation.
• Lateral prefrontal cortex is critical for contingent negative variation generation.
• Orbitofrontal cortex is not critical for contingent negative variation generation.
The prefrontal cortex (PFC) plays a central role in preparatory and anticipatory attentional processes. To investigate whether subregions of the PFC play differential roles in these processes we investigated the effect of focal lesions to either lateral prefrontal (lateral PFC; n=11) or orbitofrontal cortex (OFC; n=13) on the contingent negative variation (CNV), an electrophysiological index of preparatory brain processes. The CNV was studied using a Go/NoGo delayed response task where an auditory S1 signaled whether or not an upcoming visual S2 was a Go or a NoGo stimulus. Neither early (500–1000 ms) nor late (3200–3700 ms) phase Go trial CNV amplitude was reduced for any of the patient groups in comparison to controls. However, the lateral PFC group showed enhanced Go trial early CNV and reduced late CNV Go/NoGo differentiation. These data suggests that normal orienting and evaluation as reflected by the CNV is intact after OFC lesions. The enhanced early CNV after lateral PFC damage may be due to failure in inhibition and the reduced late CNV difference wave confirms a deficit in preparatory attention after damage to this frontal subregion.
Journal: Brain Research - Volume 1527, 21 August 2013, Pages 174–188