Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors in C6 glioma cells

► Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors. ► Induction of GDNF, BDNF and NGF mRNAs is transcription-dependent. ► Increase in GDNF gene expression is partly dependent on the Keap1/Nrf2 pathway.