Role of the NMDA receptor and iron on free radical production and brain damage following transient middle cerebral artery occlusion

► NMDA receptors mediate early free radical production in the core after tMCAO. ► Iron mediates delayed free radical production in the penumbra after tMCAO. ► NMDA receptors and iron additively contribute to delayed free radical production. ► Blockade of both NMDA receptors and iron results in additive neuroprotection.