کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4325698 1614021 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glucocorticoids dexamethasone and hydrocortisone inhibit proliferation and accelerate maturation of chicken cerebellar granule neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Glucocorticoids dexamethasone and hydrocortisone inhibit proliferation and accelerate maturation of chicken cerebellar granule neurons
چکیده انگلیسی
► We have tested GC effects on granule neurons in the chicken embryo cerebellum and in cerebellar neuronal cell culture. ► Both GCs, dexamethasone and hydrocortisone, reduce neuronal proliferation in the chicken cerebellum in vivo and in vitro. ► Dexamethasone and hydrocortisone increase neuronal differentiation in the chicken cerebellum in vivo and in vitro. ► The cytostatic agent cytosine arabinoside gives a similar effect to that of GCs in neuronal culture. ► Together these results indicate a connection between inhibition of the cell cycle and increased differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1418, 18 October 2011, Pages 32-41
نویسندگان
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