کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4325714 1614029 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Origins of endomorphin-2 immunopositive fibers and terminals in the rat medullary dorsal horn
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Origins of endomorphin-2 immunopositive fibers and terminals in the rat medullary dorsal horn
چکیده انگلیسی

Endomorphin-2-immunoreactive (EM2-IR) fibers and terminals are densely present in the medullary dorsal horn (MDH) and are key factors in regulating central nociceptive processing. However, the origins of these EM2-IR fibers and terminals remain elusive. It was hypothesized that there were at least three possible origins of the EM2-IR fibers and terminals in the MDH: intrinsic dorsal horn neurons, primary afferent fibers, and projection fibers from higher parts of the brain. Different kinds of measures were employed in the current study to elucidate this hypothesis. After intracerebral ventricle administration of colchicine, no EM2-IR neuronal cell bodies were detected in the MDH, suggesting that there was no intrinsic EM2-IR dorsal horn neuron. Disruption of bilateral primary afferents (exposed to the primary afferent neurotoxin, capsaicin) decreased bilateral EM2 expression but did not eliminate it. Transection of the trigeminal nerve sensory root significantly decreased EM2 expression on the ipsilateral but not on the contralateral MDH. After injecting FluoroGold (FG) into the MDH, FG retrogradely labeled some EM2-IR neurons in the bilateral hypothalamus and nucleus tractus solitarii (NTS), and some of the FG retrogradely labeled neurons in the ipsilateral trigeminal ganglion also showed EM2-immunoreactivities. These results indicate that EM2-IR fibers and terminals in the MDH come not only from ipsilateral primary trigeminal afferents but also from bilateral fibers from the hypothalamus and NTS.

Figure optionsDownload high-quality image (135 K)Download as PowerPoint slideHighlights
► Different measures are employed to clarify the possible origins of EM2 in the MDH.
► Ipsilateral primary trigeminal afferents are the main source of EM2 in the MDH.
► EM2 in the MDH also comes from bilateral fibers from the hypothalamus and NTS.
► There is no intrinsic EM2-immunoreactive dorsal horn neuron detected.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1410, 2 September 2011, Pages 38–47
نویسندگان
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